Experimental elimination of tumor necrosis factor in low-dose endotoxin models has variable effects on survival
| Autor: | K I Kujawa, A K Franks, L J Yaffe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide medicine.medical_treatment Immunology Drug Resistance Galactosamine Biology Carrageenan Microbiology Antibodies Pathogenesis chemistry.chemical_compound Mice Drug tolerance medicine Animals Interleukin 6 Sensitization Mice Inbred BALB C Septic shock Interleukin-6 Tumor Necrosis Factor-alpha Drug Tolerance medicine.disease Shock Septic Survival Rate Disease Models Animal Kinetics Infectious Diseases medicine.anatomical_structure Cytokine chemistry biology.protein Parasitology Tumor necrosis factor alpha Female Research Article |
| Popis: | Tumor necrosis factor alpha (TNF) is thought to play a major role in the pathogenesis of septic shock. Anti-TNF antibody was preadministered in low-dose endotoxin lethality models in which BALB/c mice were challenged with small amounts of lipopolysaccharide following their sensitization with either carrageenan (CAR) or D-galactosamine (D-GalN). Although the antibody virtually eliminated circulating TNF in both the CAR and the D-GalN models, only the D-GalN model mice were afforded survival, adding to a growing body of evidence that substances other than TNF play a key role in endotoxin-induced lethality. Further examination of sera from these mice showed a much greater elevation of interleukin-6 levels in the CAR-sensitized group than in the D-GalN-sensitized group. |
| Databáze: | OpenAIRE |
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