Quantification of global lung inflammation using volumetric 18F-FDG PET/CT parameters in locally advanced non-small-cell lung cancer patients treated with concurrent chemoradiotherapy: a comparison of photon and proton radiation therapy
| Autor: | Stephanie R. Rice, Ali Salavati, Sina Houshmand, Thomas Werner, Anusha Kalbasi, Charles B. Simone, Abass Alavi, Zeljko Vujaskovic, Babak Saboury, Chelain R. Goodman |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Lung Neoplasms Inflammation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Carcinoma Non-Small-Cell Lung Positron Emission Tomography Computed Tomography Carcinoma Proton Therapy Medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Radiation Injuries Pneumonitis Aged Retrospective Studies Photons Lung business.industry General Medicine Chemoradiotherapy Pneumonia Middle Aged medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Fdg pet ct Female Non small cell medicine.symptom business Complication Nuclear medicine |
| Zdroj: | Nuclear medicine communications. 40(6) |
| ISSN: | 1473-5628 |
| Popis: | Radiation pneumonitis is a major dose-limiting complication in thoracic radiation therapy (RT) and presents clinically in the first few months after RT. We evaluated the feasibility of quantifying pulmonary parenchymal glycolysis (PG) as a surrogate of global lung inflammation and radiation-induced pulmonary toxicity using a novel semiautomatic lung segmentation technique in non-small-cell lung cancer (NSCLC) patients and compared PG in patients treated with photon or proton RT.We evaluated 18 consecutive locally advanced NSCLC patients who underwent pretreatment and post-treatment F-FDG PET/CT treated with definitive (median: 66.6 Gy; 1.8 Gy fractions) photon or proton RT between 2010 and 2014. Lung volume segmentation was conducted using 3D Slicer by performing simple thresholding. Pulmonary PG was calculated by summing F-FDG uptake in the whole lung.In nine patients treated with photon RT, significant increases in PG in both ipsilateral (mean difference: 1400±510; P=0.02) and contralateral (mean difference: 1200±450; P=0.03) lungs were noted. In nine patients treated with proton therapy, no increase in pulmonary PG was observed in either the ipsilateral (P=0.30) or contralateral lung (P=0.98).We observed a significant increase in global lung inflammation bilaterally as measured by quantification of PG. However, no significant change in global lung inflammation was noted after proton therapy. Future larger studies are needed to determine whether this difference correlates with lower risks of radiation pneumonitis in NSCLC patients treated with proton therapy. |
| Databáze: | OpenAIRE |
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