R-CHOP(-like) treatment of diffuse large B-cell lymphoma significantly reduces CT-assessed vertebral bone density:a single center study of 111 patients

Autor: Nitesh Shekhrajka, Peter Svenssen Munksgaard, Anders Krog Vistisen, Lasse Hjort Jakobsen, Jens Brøndum Frøkjær, Peter Vestergaard, Marianne Tang Severinsen, Pernille Svendsen, Mette Østergaard Poulsen, Tarec Christoffer El-Galaly, Martin Bøgsted, Hans Erik Johnsen, Kasper Lindblad Nielsen, Paw Jensen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
Adolescent
Osteoporosis
Single Center
Antibodies
Monoclonal
Murine-Derived
Young Adult
03 medical and health sciences
0302 clinical medicine
Bone Density
Positron Emission Tomography Computed Tomography
hemic and lymphatic diseases
Hounsfield scale
Antineoplastic Combined Chemotherapy Protocols
Odds Ratio
medicine
Humans
Cyclophosphamide
Aged
Aged
80 and over
Bone mineral
business.industry
Retrospective cohort study
Hematology
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Spine
Lymphoma
Treatment Outcome
030104 developmental biology
Oncology
Doxorubicin
Vincristine
030220 oncology & carcinogenesis
Prednisolone
Prednisone
Female
Lymphoma
Large B-Cell
Diffuse
Rituximab
Tomography
X-Ray Computed
Nuclear medicine
business
Diffuse large B-cell lymphoma
Biomarkers
medicine.drug
Zdroj: Svendsen, P, Shekhrajka, N, Nielsen, K L, Vestergaard, P, Poulsen, M Ø, Vistisen, A K, Munksgaard, P S, Severinsen, M T, Jensen, P, Johnsen, H E, Jakobsen, L H, Bøgsted, M, Frøkjær, J B & El-Galaly, T C 2017, ' R-CHOP(-like) treatment of diffuse large B-cell lymphoma significantly reduces CT-assessed vertebral bone density : a single center study of 111 patients ', Leukemia and Lymphoma, vol. 58, no. 5, pp. 1105-1113 . https://doi.org/10.1080/10428194.2016.1233543
DOI: 10.1080/10428194.2016.1233543
Popis: Treatment of diffuse large B-cell lymphoma (DLBCL) with R-CHOP(-like) regimens include large cumulative doses of prednisolone. In this retrospective study, we evaluated changes in vertebral bone density (VD) in DLBCL patients by measuring CT-ascertained Hounsfield units (HU) at the L3 level. In total, 111 patients diagnosed from 2007 to 2012 and response assessed following first line treatment were included. Post-treatment VD was significantly reduced to 86% of pretreatment VD on average (p 70 years) were significantly associated with greater post-treatment VD reduction. Two years after completing R-CHOP treatment, VD remained significantly lower than baseline VD (p
Databáze: OpenAIRE
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