Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats
| Autor: | Ji-Qiang Chen, Ya-Juan Wang, Shunde Song, Qiang-min Xie, Xue-Feng Wang, Jun-Chun Chen, Huifang Tang, Ya-li Jiang, Zigang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Bordetella pertussis Article Subject Ovalbumin Phosphodiesterase 3 Rats Sprague-Dawley Downregulation and upregulation Gene expression medicine Animals Lung Pertussis Vaccine lcsh:RC705-779 biology Phosphoric Diester Hydrolases business.industry Phosphodiesterase lcsh:Diseases of the respiratory system General Medicine respiratory system biology.organism_classification Cyclic Nucleotide Phosphodiesterases Type 3 Cyclic Nucleotide Phosphodiesterases Type 4 Rats Up-Regulation respiratory tract diseases medicine.anatomical_structure PDE4D Gene Gene Expression Regulation Vaccines Inactivated 3' 5'-Cyclic-AMP Phosphodiesterases Immunology biology.protein business Research Article |
| Zdroj: | Pulmonary Medicine, Vol 2014 (2014) Pulmonary Medicine |
| ISSN: | 2090-1836 |
| DOI: | 10.1155/2014/581738 |
| Popis: | This paper indicated that inactivatedBordetella pertussis(iBp) can enhance the lung airway hyperreactivity of the rats sensitized and challenged with OVA. The mechanisms were involved in the upregulation of cAMP-PDE activity and PDE4A, PDE4D, and PDE3 gene expression in the lungs. But only PDE4 activity was different between the OVA and OVA+iBp groups, and PDE4D expression was significantly increased in iBp rats alone. So, our data suggested that cosensitization with OVA and iBp affects lung airway reactivity by modulating the lung cAMP-PDE activity and PDE4D gene expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|