Hospital waste incinerator bottom ash leachate induced cyto-genotoxicity in Allium cepa and reproductive toxicity in mice
| Autor: | Temitayo I Akinbola, Adetutu Adeyemi, Chibuisi G. Alimba, Adekunle A. Bakare, Olajumoke A. Morenikeji |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Hazardous Waste Incinerator bottom ash Health Toxicology and Mutagenesis Industrial Waste Incineration Toxicology medicine.disease_cause Plant Roots Mice Metals Heavy Onions Botany medicine Animals Leachate Medical Waste Disposal Spermatogenesis biology Reproduction Public Health Environmental and Occupational Health biology.organism_classification Spermatozoa Hospitals Seminiferous tubule medicine.anatomical_structure Bottom ash Environmental chemistry Allium Reproductive toxicity Injections Intraperitoneal Water Pollutants Chemical Germ cell Genotoxicity |
| Zdroj: | Toxicology and Industrial Health. 27:505-514 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233710391991 |
| Popis: | The potentials of hospital incinerator bottom ash leachate (HIBAL) to induce cyto-genotoxicity in Allium cepa and reproductive anomalies in the mouse were investigated. The leachate obtained from simulation of the bottom ash was analyzed for some physico-chemical parameters. The A. cepa, mouse sperm morphology and histopathological tests were carried out at concentrations ranging from 1% to 50% of the leachate sample. In A. cepa, HIBAL caused significant (p < 0.05) inhibition of root growth and induction of chromosomal aberrations. In the animal assays, there was 100% mortality at the 50% concentrations. The leachate caused insignificant (p > 0.05) concentration-dependent induction of various types of sperm morphology. There was accumulation of fluid in the seminiferous tubule lumen and necrosis of stem cells in the testes. These effects were believed to be provoked by the somatic and germ cell genotoxins, particularly the heavy metals in the leachate. Our finding is of environmental and public health significance. |
| Databáze: | OpenAIRE |
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