Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier

Autor:	Christian Gaiddon, J.-P. Collin, Meng Xiangjun, Michel Pfeffer, Ludivine Fetzer, Moussa Ali, Bastien Boff, Claude B. Sirlin
Rok vydání:	2011
Předmět:	Chemistry Antineoplastic Agents Combinatorial chemistry Redox In vitro Ruthenium Pincer movement Inorganic Chemistry Biological property Cell Line Tumor Lipophilicity Colonic Neoplasms Organometallic Compounds Organic chemistry Humans Drug Screening Assays Antitumor Cell Proliferation
Zdroj:	Dalton transactions (Cambridge, England : 2003). 40(35)
ISSN:	1477-9234
Popis:	A library of 32 organoruthenium compounds has been synthesised. Known and novel C-N cyclometalated compounds as well as N-C-N and N-N-C pincer derivatives of this metal have been used in this purpose. Most of the compounds have been tested for their in vitro antitumoral behaviours, good to excellent activities have thus been found. Several of the newly synthesized compounds pass the symbolic barrier of the nanomolar range for their IC(50) indicating a critical improvement. The level of activity is tentatively correlated to physicochemical properties of the compounds such as their Ru(III/II) redox potential and their lipophilicity (log P).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087f7b9d2dcd202aed9d52b976ff8255 https://pubmed.ncbi.nlm.nih.gov/21837342 Zobrazit plný text záznamu