Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization
| Autor: | Carolina Kolberg, Adriane Belló-Klein, Wania Aparecida Partata, Ana Paula Konzen Riffel, Jéssica Araújo de Souza, Felipe Coutinho Kullmann Duarte |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Manipulation
Spinal Nociception Lipid Peroxides Lumbosacral Plexus Pharmacology Spinal manipulation medicine.disease_cause Nitric Oxide Nitric oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Immobilization 0302 clinical medicine Lumbar medicine Animals Rats Wistar Nitrites chemistry.chemical_classification 030222 orthopedics Glutathione Peroxidase biology business.industry Superoxide Dismutase Glutathione peroxidase Catalase Stifle Rats Oxidative Stress Allodynia chemistry Hyperalgesia Models Animal biology.protein Chiropractics medicine.symptom business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | Journal of manipulative and physiological therapeutics. 42(6) |
| ISSN: | 1532-6586 |
| Popis: | Objective The purpose of our study was to evaluate the effect of manually assisted lumbar spinal manipulation therapy on tactile allodynia, peripheral nerve functional recovery, and oxidative markers in rats exposed to knee immobilization-inducing hypersensitivity. Methods Tactile allodynia and sciatic, tibial, and peroneal functional indices were assessed before the knee joint immobilization, 24 hours after the knee cast removal, and 24 hours after 3 weeks of lumbar therapy with the Activator Adjusting Instrument, model 4 (AAI 4). Subsequently, the blood was collected from each rat, and oxidative markers such as lipid hydroperoxide levels; nitric oxide metabolites; and superoxide dismutase, catalase, and glutathione peroxidase activities were assessed. Results The AAI 4 improved the immobilization-induced allodynia and recovered the peripheral nerve functional indices impaired after knee immobilization. Immobilized rats treated with AAI 4 therapy presented a lack of significant changes in lipid hydroperoxides and nitric oxide metabolites in the plasma contrasting with rats that were kept freely in their cages, with no therapy applied, which presented elevated lipid hydroperoxides levels. Also, the antioxidant catalase enzymatic activity decreased in the blood of rats immobilized and treated with AAI 4. Conclusion These results suggest that manually assisted lumbar spinal manipulation therapy modulates systemic oxidative stress, which possibly contributes to the analgesia and recovery of peripheral nerve functionality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect