Diagnosis of mild Alzheimer disease through the analysis of eye movements during reading
| Autor: | Liliana Raquel Castro, Marcela Schumacher, Osvaldo Agamennoni, Gerardo Abel Fernández |
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| Rok vydání: | 2015 |
| Předmět: |
Male
CIENCIAS MÉDICAS Y DE LA SALUD Eye Movements purl.org/becyt/ford/3.5 [https] Fixation Ocular Alzheimer Disease Humans Attention Prefrontal cortex Aged Analysis of Variance Linear Mixed-Effect Models Working memory General Neuroscience Eye movement Cognition General Medicine Middle Aged Fixation (psychology) Semantics Otras Ciencias Médicas Comprehension Reading Eyetracking Signal Analys Saccade Linear Models Cognitive Impairments Female purl.org/becyt/ford/3 [https] Psychology Sentence Cognitive psychology |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1757-448X 0219-6352 |
| Popis: | Reading requires the integration of several central cognitive subsystems, ranging from attention and oculomotor control to word identification and language comprehension. Reading saccades and fixations contain information that can be correlated with word properties. When reading a sentence, the brain must decide where to direct the next saccade according to what has been read up to the actual fixation. In this process, the retrieval memory brings information about the current word features and attributes into working memory. According to this information, the prefrontal cortex predicts and triggers the next saccade. The frequency and cloze predictability of the fixated word, the preceding words and the upcoming ones affect when and where the eyes will move next. In this paper we present a diagnostic technique for early stage cognitive impairment detection by analyzing eye movements during reading proverbs. We performed a case-control study involving 20 patients with probable Alzheimer's disease and 40 age-matched, healthy control patients. The measurements were analyzed using linear mixed-effects models, revealing that eye movement behavior while reading can provide valuable information about whether a person is cognitively impaired. To the best of our knowledge, this is the first study using word-based properties, proverbs and linear mixed-effect models for identifying cognitive abnormalities. Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina Fil: Castro, Liliana Raquel. Universidad Nacional del Sur. Departamento de Matemática; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina Fil: Schumacher, Marcela Silvana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina Fil: Agamennoni, Osvaldo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina |
| Databáze: | OpenAIRE |
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