Sphingomyelin in erythrocyte membranes increases the total cholesterol content of erythrocyte membranes in patients with acute coronary syndrome
| Autor: | Changhao Wu, Zi-ping Cheng, Yan Xu, Mengzuo Wu, Bin Chen, Kexiang Tu, Lingxin Pan, Xuhua Chen, Jianhua Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty Coronary Angiography Logistic regression Gastroenterology Angina Coronary artery disease Risk Factors Internal medicine Odds Ratio medicine Humans Angina Stable Acute Coronary Syndrome Aged business.industry Erythrocyte Membrane Confounding Case-control study General Medicine Odds ratio Middle Aged medicine.disease Sphingomyelins Up-Regulation Cholesterol Logistic Models medicine.anatomical_structure Case-Control Studies Multivariate Analysis Immunology Disease Progression Female Cardiology and Cardiovascular Medicine business Biomarkers Artery |
| Zdroj: | Coronary Artery Disease. 24:361-367 |
| ISSN: | 0954-6928 |
| Popis: | To investigate whether the sphingomyelin content of erythrocyte membranes (SEM) is changed in patients with acute coronary syndrome (ACS) and determine the correlation between SEM and the total cholesterol content of erythrocyte membranes (CEM).The SEM and CEM levels were measured in 354 patients undergoing coronary artery angiography in three different groups: ACS patients (n=199), patients with stable angina pectoris (SAP) (n=82), and controls (n=73).The SEM levels in the ACS group were significantly higher than those of the SAP group. The SEM levels were correlated positively with the CEM levels in patients with coronary artery disease. Multivariable logistic regression analysis showed that patients with higher levels of both SEM and CEM had an 8.569-fold greater risk of developing ACS than other patients, after adjusting for all potential confounding variables.Elevated SEM and CEM levels showed both independent and combined correlations with the occurrence of ACS and were positively correlated with each other in patients with coronary artery disease. These data suggest that the increased levels of SEM may play a role in the progression to plaque instability in ACS and may be the mechanisms underlying elevated levels of CEM in patients with ACS. |
| Databáze: | OpenAIRE |
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