Effect of radiotherapy on survival in advanced hepatocellular carcinoma patients treated with sorafenib: a nationwide cancer-registry-based study

Autor: Yi-Chen Chen, Chung-Han Ho, Ching-Chieh Yang, Shou-Sheng Chu, Hung-Chang Wu, Yu-Hsuan Kuo, Shih-Chang Wang, Wen-Shan Liu
Rok vydání: 2020
Předmět:
Oncology
Male
Databases
Factual
Hepatocellular carcinoma
medicine.medical_treatment
urologic and male genital diseases
0302 clinical medicine
heterocyclic compounds
030212 general & internal medicine
Registries
Cancer
Multidisciplinary
Medical record
Standard treatment
Liver Neoplasms
Middle Aged
Sorafenib
Combined Modality Therapy
female genital diseases and pregnancy complications
Survival Rate
Treatment Outcome
030220 oncology & carcinogenesis
Cohort
Medicine
medicine.drug
Adult
medicine.medical_specialty
Carcinoma
Hepatocellular
Science
Article
03 medical and health sciences
Internal medicine
medicine
Humans
neoplasms
Protein Kinase Inhibitors
Aged
Proportional Hazards Models
business.industry
Proportional hazards model
medicine.disease
digestive system diseases
Cancer registry
Radiation therapy
business
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
ISSN: 2045-2322
Popis: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC) patients. This study aims to determine whether combining radiotherapy with sorafenib administration increases its efficacy. The study cohort included 4763 patients with diagnosed advanced HCC who received sorafenib between January 2012 and December 2015, as reported in medical records in the Taiwan Cancer Registry database. The effect of sorafenib with or without radiotherapy on survival was calculated using the Kaplan–Meier method and compared using the log-rank test. A Cox proportional hazards model was used for multivariate analysis. Patients receiving sorafenib plus radiotherapy had greater 1-year survival than did those receiving sorafenib alone (P
Databáze: OpenAIRE
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