Towards multifocal ultrasonic neural stimulation II: design considerations for an acoustic retinal prosthesis
| Autor: | Esther Zemel, Omer Naor, Shy Shoham, Yoni Hertzberg, Eitan Kimmel |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
genetic structures
Computer science Retinal stimulation Holography Biomedical Engineering Tetrodotoxin Prosthesis Design Retina law.invention Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine law Electroretinography medicine Animals Humans Computer Simulation Ultrasonics Computer vision Anesthetics Local 030304 developmental biology 0303 health sciences Modality (human–computer interaction) business.industry Retinal Degeneration Ultrasound Rats Visual Prosthesis medicine.anatomical_structure Acoustic Stimulation Retinal Prosthesis Neural stimulation Evoked Potentials Visual Feasibility Studies Ultrasonic sensor Artificial intelligence Safety business Algorithms Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neural Engineering |
| ISSN: | 1741-2552 1741-2560 |
| DOI: | 10.1088/1741-2560/9/2/026006 |
| Popis: | Ultrasound waves, widely used as a non-invasive diagnostic modality, were recently shown to stimulate neuronal activity. Functionally meaningful stimulation, as is required in order to form a unified percept, requires the dynamic generation of simultaneous stimulation patterns. In this paper, we examine the general feasibility and properties of an acoustic retinal prosthesis, a new vision restoration strategy that will combine ultrasonic neuro-stimulation and ultrasonic field sculpting technology towards non-invasive artificial stimulation of surviving neurons in a degenerating retina. We explain the conceptual framework for such a device, study its feasibility in an in vivo ultrasonic retinal stimulation study and discuss the associated design considerations and tradeoffs. Finally, we simulate and experimentally validate a new holographic method—the angular spectrum-GSW—for efficient generation of uniform and accurate continuous ultrasound patterns. This method provides a powerful, flexible solution to the problem of projecting complex acoustic images onto structures like the retina. (Some figures in this article are in colour only in the electronic version) |
| Databáze: | OpenAIRE |
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