Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: A novel tailored treatment strategy
| Autor: | Laura Bianchi, Debora Maruca, Vito Trinchieri, Eugenio Nelson Cavallari, Massimiliano De Angelis, Paolo Vassalini, Fabrizia Toscanella, S. Venosi, Ombretta Martinelli, Gabriella d'Ettorre, Alessandra Oliva, Giancarlo Ceccarelli, Luca Laghi |
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| Přispěvatelé: | Venosi S., Ceccarelli G., De Angelis M., Laghi L., Bianchi L., Martinelli O., Maruca D., Cavallari E.N., Toscanella F., Vassalini P., Trinchieri V., Oliva A., D'Ettorre G. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Administration Topical 030106 microbiology Bacteriotherapy topical probiotic metabolomic wound wound care wound healing antimicrobial resistance lcsh:Medicine Wound healing Metabolomic Antimicrobial resistance Gastroenterology General Biochemistry Genetics and Molecular Biology law.invention Lesion Pathogenesis Translational Research Biomedical 03 medical and health sciences Probiotic Wound care law Ischemia Internal medicine Skin Ulcer Topical probiotic Wound medicine Humans Skin Aged 80 and over Leg business.industry Probiotics Research lcsh:R General Medicine Critical limb ischemia medicine.disease 030104 developmental biology Chronic Disease Metabolome Wound Infection Female medicine.symptom business Dysbiosis |
| Zdroj: | Journal of Translational Medicine Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019) |
| Popis: | Background A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor. Aim: clinical report An 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria. Methods Microbiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy. Results During the treatment course, a progressive healing of the lesion was observed with microbiological resolution of the polymicrobial infection of the wound. Metabolomic analysis showed a significant difference in the local concentration of propionate, 2-hydroxyisovalerate, 2-oxoisocaproate, 2,3-butanediol, putrescine, thymine, and trimethylamine before and after bacteriotherapy. Conclusion The microbiological and metabolomic results seem to confirm the usefulness of complementary probiotic treatment in difficult-to-treat infected wounds. Further investigations are needed to confirm these preliminary findings. |
| Databáze: | OpenAIRE |
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