The prediction of progression-free and overall survival in women with an advanced stage of epithelial ovarian carcinoma
| Autor: | Rhm Dykgraaf, Anca C. Ansink, D. de Jong, C.G. Gerestein, Curt W. Burger, Mel van der Burg, A. Baalbergen, G.S. Kooi, Mjc Eijkemans |
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| Přispěvatelé: | Obstetrics & Gynecology, Public Health, Medical Oncology |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Blood Platelets medicine.medical_specialty medicine.medical_treatment Disease-Free Survival Hemoglobins SDG 3 - Good Health and Well-being Internal medicine Ovarian carcinoma Antineoplastic Combined Chemotherapy Protocols medicine Humans Progression-free survival Stage (cooking) Aged Retrospective Studies Aged 80 and over Ovarian Neoplasms Chemotherapy Proportional hazards model business.industry Platelet Count Obstetrics and Gynecology Retrospective cohort study Nomogram Middle Aged medicine.disease Combined Modality Therapy Surgery Nomograms Treatment Outcome Female Neoplasm Recurrence Local Ovarian cancer business Follow-Up Studies |
| Zdroj: | Bjog-An International Journal of Obstetrics and Gynaecology, 116(3), 372-380. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1470-0328 |
| DOI: | 10.1111/j.1471-0528.2008.02033.x |
| Popis: | Objective Prognosis in women with ovarian cancer mainly depends on International Federation of Gynecology and Obstetrics stage and the ability to perform optimal cytoreductive surgery. Since ovarian cancer has a heterogeneous presentation and clinical course, predicting progression-free survival (PFS) and overall survival (OS) in the individual patient is difficult. The objective of this study was to determine predictors of PFS and OS in women with advanced stage epithelial ovarian cancer (EOC) after primary cytoreductive surgery and first-line platinum-based chemotherapy. Design Retrospective observational study. Setting Two teaching hospitals and one university hospital in the south-western part of the Netherlands. Population Women with advanced stage EOC. Methods All women who underwent primary cytoreductive surgery for advanced stage EOC followed by first-line platinum-based chemotherapy between January 1998 and October 2004 were identified. To investigate independent predictors of PFS and OS, a Cox’ proportional hazard model was used. Nomograms were generated with the identified predictive parameters. Main outcome measures The primary outcome measure was OS and the secondary outcome measures were response and PFS. Results A total of 118 women entered the study protocol. Median PFS and OS were 15 and 44 months, respectively. Preoperative platelet count (P = 0.007), and residual disease |
| Databáze: | OpenAIRE |
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