Vitamin D Status and Indices of Bone Turnover in Older European Adults
| Autor: | Elizabeth E.A. Simpson, Charles Coudray, Kelly M. Seamans, Lisa Scully, Isabelle Hininger-Favier, Donatella Ciarapica, Maude Andrillo-Sanchez, Angela Polito, Nathalie Meunier, Kevin D. Cashman, Barbara J. Stewart-Knox, Jacqueline M. O'Connor, Tom R. Hill |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Department of Nutritional Science, National Institute for Research on Food and Nutrition, Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Division of Psychology, Glasgow Caledonian University, Dynamique Musculaire et Métabolisme (DMEM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Glasgow Caledonian University (GCU) |
| Rok vydání: | 2011 |
| Předmět: |
Male
Aging medicine.medical_specialty Deoxypyridinoline bone turnover vitamin D deficiency [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Urinary system Osteocalcin Medicine (miscellaneous) Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine older Vitamin D and neurology Humans Medicine 030212 general & internal medicine Amino Acids Vitamin D 030223 otorhinolaryngology ComputingMilieux_MISCELLANEOUS Aged Nutrition and Dietetics Pyridinoline biology business.industry General Medicine Middle Aged Alkaline Phosphatase medicine.disease 25-hydroxyvitamin D Europe Cross-Sectional Studies Endocrinology chemistry biology.protein Alkaline phosphatase Female Bone Remodeling business Biomarkers |
| Zdroj: | International Journal for Vitamin and Nutrition Research International Journal for Vitamin and Nutrition Research, Hogrefe, 2011, 81 (5), pp.277-285. ⟨10.1024/0300-9831/a000075⟩ International Journal for Vitamin and Nutrition Research, 2011, 81 (5), pp.277-285. ⟨10.1024/0300-9831/a000075⟩ |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831/a000075 |
| Popis: | An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an elevated rate of bone turnover in older adults is unclear. The objective of this study was to investigate the associations between 25-hydroxyvitamin D and biochemical markers of bone turnover in an older, pan-European cohort. 25-hydroxyvitamin D and serum markers of bone-formation (osteocalcin and bone-specific alkaline phosphatase) were assessed by ELISA, while urinary markers of bone-resorption (pyridinoline and deoxypyridinoline) were assessed by HPLC. Six percent, 36 %, and 64 % of subjects had 25-hydroxyvitamin D concentrations < 25, < 50, and < 80 nmol/L throughout the year, respectively. 25-hydroxyvitamin D was significantly and inversely correlated with serum bone-specific alkaline phosphatase (r = 0.119; p = 0.022) and urinary pyridinoline (r = 0.207; p < 0.0001) and deoxypyridinoline (r = 0.230; p < 0.0001). Stratification on the basis of tertiles [T] of 25-hydroxyvitamin D (< 47.6 [T1]; 47.6 - 85.8 [T2]; > 85.8 [T3] nmol/L), showed that urinary pyridinoline and deoxypyridinoline were significantly lower in subjects in the 2nd and 3rd compared to the 1st tertile (p < 0.015). Low vitamin D status (< 50 nmol/L) was associated with an increased rate of bone turnover in this older pan-European cohort. |
| Databáze: | OpenAIRE |
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