Cell-Penetrating Peptides: a Useful Tool for the Delivery of Various Cargoes Into Cells
| Autor: | Eliška Böhmová, T Etrych, Daniela Machová, K Venclíková, Michal Pechar, Olga Janoušková, Robert Pola |
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| Předmět: |
0301 basic medicine
Cellular membrane Physiology Chemistry media_common.quotation_subject Cell Cell Membrane General Medicine Computational biology Cell-Penetrating Peptides Endocytosis Cell membrane 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Drug Delivery Systems 030220 oncology & carcinogenesis medicine Animals Humans Amino Acid Sequence Internalization media_common |
| Zdroj: | ResearcherID |
| Popis: | Cell-penetrating compounds are substances that enhance the cellular uptake of various molecular cargoes that do not easily cross the cellular membrane. The majority of cell-penetrating compounds described in the literature are cell-penetrating peptides (CPPs). This review summarizes the various structural types of cell-penetrating compounds, with the main focus on CPPs. The authors present a brief overview of the history of CPPs, discuss the various types of conjugation of CPPs to biologically active cargoes intended for cell internalization, examine the cell-entry mechanisms of CPPs, and report on the applications of CPPs in research and in preclinical and clinical studies. |
| Databáze: | OpenAIRE |
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