Efficacy and Tolerability of Solifenacin 5 mg Fixed Dose in Korean Children with Newly Diagnosed Idiopathic Overactive Bladder: a Multicenter Prospective Study
| Autor: | Won Yeol Cho, Dong Soo Ryu, Sungchan Park, Jae Min Chung, Sang Don Lee, Dong Il Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Solifenacin Succinate
Male medicine.medical_specialty Efficacy media_common.quotation_subject Urology 030232 urology & nephrology Urination Urinary incontinence Xerostomia 03 medical and health sciences 0302 clinical medicine Asian People Republic of Korea medicine Humans Prospective Studies Adverse effect Prospective cohort study Child Fatigue media_common Solifenacin business.industry Urinary Bladder Overactive General Medicine Drug Tolerance medicine.disease Tolerability Treatment Outcome Urinary Incontinence Overactive bladder 030220 oncology & carcinogenesis Child Preschool Urological Agents Original Article Female medicine.symptom business Overactive Bladder Anticholinergics medicine.drug |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | We investigated the efficacy and tolerability of solifenacin 5 mg fixed dose in children with newly diagnosed idiopathic overactive bladder (OAB). A total of 34 children (male/female patients = 16/18) aged under 13 years (mean age: 7.2 ± 2.3; range: 5–12) who were newly diagnosed with OAB from January 2012 to September 2014 were prospectively evaluated with open-label protocol. All patients were treated with solifenacin 5 mg fixed dose once daily for at least 4 weeks. The efficacy and tolerability of solifenacin were evaluated 4, 8, and 12 weeks after the initiation of treatment. The mean voiding frequency during daytime was decreased from 9.4 ± 3.0 to 6.5 ± 2.3 times after the 12-week treatment (P < 0.001). The mean total OAB symptom score (OABSS) decreased from 7.7 ± 4.2 to 3.1 ± 3.1 after the 12-week treatment (P < 0.001). The urgency and urgency urinary incontinence (UUI) domains significantly improved from the 12-week treatment, and complete resolution of urgency occurred in 38.9% of patients and the percentage of children with UUI among urgent patients decreased from 79.4% to 57.1%. According to 3-day voiding diaries, the average bladder capacity increased from 90.4 ± 44.4 to 156.2 ± 67.3 mL (P < 0.001). Drug-induced adverse effects (AEs) were reported in 7 patients (20.6%). Our results indicate that solifenacin 5 mg fixed dose is effective against OAB symptoms, and its tolerability is acceptable without significant AEs in children with OAB. Graphical Abstract |
| Databáze: | OpenAIRE |
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