On the development of the hepatopancreatic ductal system
| Autor: | Didier Y.R. Stainier, Alethia Villasenor |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Organ induction Endoderm Morphogenesis Intrahepatic bile ducts Foregut Cell Biology Anatomy Biology Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Liver Multipotent Stem Cell medicine Humans Signal transduction Pancreas Digestive System Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. 66:69-80 |
| ISSN: | 1084-9521 |
| DOI: | 10.1016/j.semcdb.2017.02.003 |
| Popis: | The hepatopancreatic ductal system is the collection of ducts that connect the liver and pancreas to the digestive tract. The formation of this system is necessary for the transport of exocrine secretions, for the correct assembly of the pancreatobiliary ductal system, and for the overall function of the digestive system. Studies on endoderm organ formation have significantly advanced our understanding of the molecular mechanisms that govern organ induction, organ specification and morphogenesis of the major foregut-derived organs. However, little is known about the mechanisms that control the development of the hepatopancreatic ductal system. Here, we provide a description of the different components of the system, summarize its development from the endoderm to a complex system of tubes, list the pathologies produced by anomalies in its development, as well as the molecules and signaling pathways that are known to be involved in its formation. Finally, we discuss its proposed potential as a multipotent cell reservoir and the unresolved questions in the field. |
| Databáze: | OpenAIRE |
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