Rapid progression of disease in two cases of undifferentiated endometrial carcinoma
| Autor: | Leslie M. Randall, Krista S. Pfaendler |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis Undifferentiated endometrial carcinoma medicine.medical_treatment Undifferentiated Endometrial Carcinoma Case Report Disease lcsh:Gynecology and obstetrics lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Endometrial cancer Internal medicine medicine Recurrent disease Effective treatment lcsh:RG1-991 030219 obstetrics & reproductive medicine business.industry Disease progression Obstetrics and Gynecology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 3. Good health Dedifferentiated endometrial carcinoma 030220 oncology & carcinogenesis business Adjuvant |
| Zdroj: | Gynecologic Oncology Reports, Vol 27, Iss, Pp 65-68 (2019) Pfaendler, Krista S; & Randall, Leslie M. (2019). Rapid progression of disease in two cases of undifferentiated endometrial carcinoma.. Gynecologic oncology reports, 27, 65-68. doi: 10.1016/j.gore.2019.01.004. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6bt5c0tn Gynecologic Oncology Reports |
| ISSN: | 2352-5789 |
| DOI: | 10.1016/j.gore.2019.01.004 |
| Popis: | Undifferentiated endometrial carcinoma, a rare histopathologic diagnosis, has a poor prognosis with high risk of progression during or shortly after completion of adjuvant treatment. We present two cases of undifferentiated endometrial carcinoma: one in a postmenopausal female who experienced recurrent disease immediately after completion of adjuvant treatment and one in a premenopausal female who experienced disease progression while receiving adjuvant treatment. These cases exemplify the aggressive behavior of undifferentiated endometrial carcinoma and suggest the need for a more effective treatment in the upfront setting than the current standard of care for endometrioid endometrial adenocarcinoma. Highlights • Undifferentiated endometrial cancer represents an aggressive subset of endometrial cancer. • Limited literature is available to guide management. • High rates of loss of mismatch repair protein expression have been demonstrated. |
| Databáze: | OpenAIRE |
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