Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension
| Autor: | Nicholas K. Hayward, Agatha Gambino, Marian M. Cahill, Janet C. Wanstall, Daniela Bellomo, Trina K Jeffery, Graham F. Kay |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary Circulation
Vascular Endothelial Growth Factor B medicine.medical_specialty Physiology Hypertension Pulmonary Endothelial Growth Factors Pulmonary Artery Mice Right ventricular hypertrophy Physiology (medical) Internal medicine medicine.artery medicine Animals Hypoxia Mice Knockout Lung Hypertrophy Right Ventricular business.industry Anatomy Hypoxia (medical) medicine.disease Pulmonary hypertension medicine.anatomical_structure Hematocrit Ventricle Chronic Disease Pulmonary artery Ventricular pressure Cardiology Female medicine.symptom Tunica Media Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Cardiovascular Research. 55:361-368 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(02)00440-6 |
| Popis: | Objective : To test the hypothesis that Vegf-B contributes to the pulmonary vascular remodelling, and the associated pulmonary hypertension, induced by exposure of mice to chronic hypoxia. Methods : Right ventricular systolic pressure, the ratio of right ventricle/\[left ventricle+septum\] (RV/[LV+S]) and the thickness of the media (relative to vessel diameter) of intralobar pulmonary arteries (o.d. 50–150 and 151–420 μm) were determined in Vegfb knockout mice ( Vegfb −/−; n = 17) and corresponding wild-type mice ( Vegfb +/+; n = 17) exposed to chronic hypoxia (10% oxygen) or housed in room air (normoxia) for 4 weeks. Results : In Vegfb +/+ mice hypoxia caused (i) pulmonary hypertension (a 70% increase in right ventricular systolic pressure compared with normoxic Vegfb +/+ mice; P |
| Databáze: | OpenAIRE |
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