A modified clinicopathological tumor staging system for survival prediction of patients with penile cancer
| Autor: | Alcides Chaux, Fang Jian Zhou, Xiang Li, Zhuo Wei Liu, Zai Shang Li, Qi Lin Wang, Yong Hong Lei, Georges J. Netto, Hong Liao, Arthur L. Burnett, Yong Hong Li, Yong Tang, Hui Li, Xiao Feng Chen, Ying Ming Xiao, Jiun Hung Geng, Qi Wu Mi, Hui Lan Rao, Antonio Augusto Ornellas, Jun Hang Luo, Bin Wang, Zi Ke Qin, Christian Schwentner, Peng Chen, Kai Yao, Zi Jun Zou, Nan Liu, Hui Han |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Staging Lymphovascular invasion medicine.medical_treatment Penile Neoplasm 030232 urology & nephrology lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine medicine Penile cancer Humans Embolization Stage (cooking) Penile Neoplasms Neoplasm Staging Lymph node metastasis business.industry Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Lymphovascular Lymph node excision Oncology 030220 oncology & carcinogenesis Lymphatic Metastasis Original Article Radiology business |
| Zdroj: | Cancer Communications Cancer Communications, Vol 38, Iss 1, Pp 1-10 (2018) |
| ISSN: | 2523-3548 |
| Popis: | Background The 8th American Joint Committee on Cancer tumor–node–metastasis (AJCC-TNM) staging system is based on a few retrospective single-center studies. We aimed to test the prognostic validity of the staging system and to determine whether a modified clinicopathological tumor staging system that includes lymphovascular embolization could increase the accuracy of prognostic prediction for patients with stage T2–3 penile cancer. Methods A training cohort of 411 patients who were treated at 2 centers in China and Brazil between 2000 and 2015 were staged according to the 8th AJCC-TNM staging system. The internal validation was analyzed by bootstrap-corrected C-indexes (resampled 1000 times). Data from 436 patients who were treated at 15 centers over four continents were used for external validation. Results A survivorship overlap was observed between T2 and T3 patients (P = 0.587) classified according to the 8th AJCC-TNM staging system. Lymphovascular embolization was a significant prognostic factor for metastasis and survival (all P |
| Databáze: | OpenAIRE |
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