Goniolandrene A and B from Goniothalamus macrophyllus
| Autor: | Tomoyo Hasuda, Koichi Takeya, Norkamilah Abdullah, Yukio Hitotsuyanagi, Chee Yan Choo, Sharinah Ideris, Marc Diederich, Hamidah Sahibul-Anwar |
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| Rok vydání: | 2013 |
| Předmět: |
Goniothalamus macrophyllus
Stereochemistry Plant Roots Inhibitory Concentration 50 chemistry.chemical_compound Cell Line Tumor Drug Discovery Ic50 values Animals Benzofurans Pharmacology Chloroform Molecular Structure biology Leukemia P388 Plant Extracts Butanol Malaysia Absolute configuration General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Goniothalamus chemistry Chromones Pyrones Annonaceae Goniolandrene-B Heterocyclic Compounds 3-Ring Phytotherapy |
| Zdroj: | Fitoterapia. 88:1-6 |
| ISSN: | 0367-326X |
| Popis: | Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compounds with two new compounds, namely goniolandrene-A (1), -B (2). The absolute configuration of goniolandrene B (2) was established by circular dichrosim. The compounds were cytotoxic against the P388 cells with IC50 values ranging from 0.42 to 160 μM. Goniothalamin (3) exhibited the highest inhibition of 0.42 μM. |
| Databáze: | OpenAIRE |
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