Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds
| Autor: | Ik-Hyeon Paik, Gary H. Posner, Kristina Borstnik, Theresa A. Shapiro |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Drug
Plasmodium Trioxane media_common.quotation_subject Yingzhaosu A Pharmacology Biology Antimalarials chemistry.chemical_compound medicine Animals Artemisinin media_common Rational design Bridged Bicyclo Compounds Heterocyclic medicine.disease Artemisinins Peroxides Infectious Diseases Drug development chemistry Drug Design Parasitology Sesquiterpenes Malaria medicine.drug |
| Zdroj: | International Journal for Parasitology. 32:1661-1667 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/s0020-7519(02)00195-9 |
| Popis: | Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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