Prevalence and Predictors of Antibiotic Administration during Pregnancy and Birth
| Autor: | Anne Louise Bischoff, Jakob Stokholm, Karen A. Krogfelt, Charlotte Giwercman Carson, Susanne Schjørring, Anne Mølgaard, Louise Pedersen, Hans Bisgaard, Klaus Bønnelykke, Nilofar V. Følsgaard, Bo L. Chawes |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Denmark Science Administration Oral Cohort Studies Drug Therapy Pregnancy Risk Factors Odds Ratio Prevalence medicine Humans Childbirth Pregnancy Complications Infectious Prospective cohort study Life Style Asthma Multidisciplinary Obstetrics business.industry Parturition Gestational age Odds ratio medicine.disease Anti-Bacterial Agents Cohort Medicine Female business Maternal Age Research Article Cohort study |
| Zdroj: | PLoS ONE, Vol 8, Iss 12, p e82932 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundAntibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factors.Methods706 pregnant women from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) pregnancy cohort participated in this analysis. Detailed information on oral antibiotic prescriptions during pregnancy filled at the pharmacy was obtained and verified longitudinally. Information on intrapartum antibiotics, social, and lifestyle-factors was obtained by personal interviews.ResultsThe prevalence of antibiotic use was 37% during pregnancy and 33% intrapartum. Lower maternal age at birth; adjusted odds ratio (aOR) 0.94, 95% CI, [0.90-0.98], p = 0.003 and maternal smoking; aOR 1.97, 95% CI, [1.07-3.63], p = 0.030 were associated with use of antibiotics for urinary tract infection during pregnancy. Maternal educational level (low vs. high), aOR 2.32, 95% CI, [1.24-4.35], p = 0.011, maternal asthma; aOR 1.99, 95% CI, [1.33-2.98], p < 0.001 and previous childbirth; aOR 1.80, 95% CI, [1.21-2.66], p = 0.004 were associated with use of antibiotics for respiratory tract infection during pregnancy. Lower gestational age; aOR 0.72, 95% CI, [0.61-0.85], p < 0.001, maternal smoking; aOR 2.84, 95% CI, [1.33-6.06], p = 0.007, and nulliparity; aOR 1.79, 95% CI, [1.06-3.02], p = 0.030 were associated with administration of intrapartum antibiotics in women giving birth vaginally.ConclusionAntibiotic administration during pregnancy and birth may be influenced by social and lifestyle-factors. Understanding such risk factors may guide preventive strategies in order to avoid unnecessary use of antibiotics. |
| Databáze: | OpenAIRE |
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