High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways
| Autor: | Feng Lin Cao, Ke Jin, Nancy J. Olsen, Julie Wang, Ximei Zhang, Xiaojiang Hu, Song Guo Zheng, Ze Xiu Xiao, Baoqing Sun, Zhigang Chen, Joseph A. Bellanti |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research T-Lymphocytes T cell Immunology Antigen-Presenting Cells lcsh:Medicine p38 Mitogen-Activated Protein Kinases Article Proinflammatory cytokine Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology immune system diseases Genetics Animals Humans Lupus Erythematosus Systemic Medicine Sodium Chloride Dietary Salt intake skin and connective tissue diseases lcsh:QH301-705.5 Autoantibodies Systemic lupus erythematosus business.industry lcsh:R Autoantibody Dendritic Cells medicine.disease STAT1 Transcription Factor 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Signal transduction business Signal Transduction 030215 immunology |
| Zdroj: | Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-13 (2020) Signal Transduction and Targeted Therapy |
| ISSN: | 2059-3635 |
| DOI: | 10.1038/s41392-020-0139-5 |
| Popis: | The increased incidence of systemic lupus erythematosus (SLE) in recent decades might be related to changes in modern dietary habits. Since sodium chloride (NaCl) promotes pathogenic T cell responses, we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases, including SLE. Given the importance of dendritic cells (DCs) in the pathogenesis of SLE, we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model. We used an induced lupus model in which bone marrow-derived dendritic cells (BMDCs) were incubated with activated lymphocyte-derived DNA (ALD-DNA) and transferred into C57BL/6 recipient mice. We observed that a high-salt diet (HSD) markedly exacerbated lupus progression, which was accompanied by increased DC activation. NaCl treatment also stimulated the maturation, activation and antigen-presenting ability of DCs in vitro. Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus. These mice had increased production of autoantibodies and proinflammatory cytokines, more pronounced splenomegaly and lymphadenopathy, and enhanced pathological renal lesions. The p38 MAPK–STAT1 pathway played an important role in NaCl-induced DC immune activities. Taken together, our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE. Thus, changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases. |
| Databáze: | OpenAIRE |
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