The impact of gender, age, race/ethnicity, and stage on quality of life in a spectrum of cutaneous lymphomas
| Autor: | Estella Barrios, Joycelynne Palmer, X. Martinez, Arnab Chowdhury, Matthew Loscalzo, Steven T. Rosen, Farah Abdulla, Jasmine Zain, Tracey Stiller, Christiane Querfeld |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms media_common.quotation_subject Disease Cutaneous lymphoma Article 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Ethnicity Medicine Humans Sezary Syndrome 030212 general & internal medicine media_common Mycosis fungoides business.industry medicine.disease humanities Distress Cross-Sectional Studies Oncology 030220 oncology & carcinogenesis Quality of Life Population study Female Worry business Psychosocial |
| Zdroj: | Support Care Cancer |
| ISSN: | 1433-7339 |
| Popis: | PURPOSE: Cutaneous lymphomas (CLs) are a group of rare, potentially disfiguring and disabling cancers that can have a significant impact on quality of life (QoL). While previous studies have shown that mycosis fungoides (MF) and Sézary syndrome (SS) impair QoL, the effect of other types of CL on QoL has not been evaluated. OBJECTIVE: To determine the impact of disease on QoL in all CL patients and to assess how QoL between the CL subtypes varies by demographic and clinical factors. METHODS: The Cutaneous Lymphoma Distress Questionnaire (CL-DQ) was used to assess QoL. All CL patients seen in a multidisciplinary CL clinic were screened for eligibility. Questionnaire responses were collected over a 22-month period between 2017 and 2019. A cross-sectional analysis of CL-DQ scores from an initial visit was performed to determine the effect of disease on QoL across CL subtypes and the potential impact of patient demographics, CL subtype, and type of treatment. RESULTS: The study population consisted of 151 patients presenting with distinct types of cutaneous B- and T-cell lymphomas. Notable across the study population were the findings of frustration (44%), worry about progress/spread (43%), itching/pruritus (32%), and embarrassment/shame (28%). QoL was found to be most negatively affected in SS patients, females, younger patients, Black patients, and those with advanced stages of MF/SS. CONCLUSIONS: Impairment of QoL due to CL correlates with gender, age, race/ethnicity, and stage of MF/SS. While the negative impact on QoL is most pronounced in SS patients, other CL subtypes also affect QoL and impact psychosocial distress. Our findings highlight the need for QoL assessment in all CL patients and further examination of disparities noted across demographic groups. |
| Databáze: | OpenAIRE |
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