A comparison of intracerebral and intraperitoneal injections of melatonin and its precursors on 131 I uptake by the thyroid glands of rats
| Autor: | James Hurley, Nicholas D. De Prospo |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Serotonin Time Factors Immunology Central nervous system Thyroid Gland Biology Toxicology Injections Melatonin 5-Hydroxytryptophan Pineal gland Oxygen Consumption Internal medicine Iodine Isotopes medicine Animals Pharmacology (medical) Mode of action Pharmacology Diminution Thyroid Body Weight Rats Inbred Strains Organ Size Rats Endocrinology medicine.anatomical_structure Depression Chemical Pituitary Gland Female Injections Intraperitoneal Hormone medicine.drug Iodine |
| Zdroj: | Agents and actions. 2(1) |
| ISSN: | 0065-4299 |
| Popis: | Daily intracerebral injections of 100 micrograms/100 grams body weight of melatonin or one of its precursors (N-acetylserotonin, serotonin hydrogen oxalate, and 5-hydroxytryptophan) for ten days caused a diminution in the rate of oxygen consumption and a depression in131I uptake by the thyroid glands of female Sprague-Dawley rats. The findings were all statistically significant except for those on iodine uptake in serotonin-treated animals. As a basis for comparison and in an attempt to elicit information as to mode of action, a group of control rats were given intraperitoneal injections of the hormone and its precursors. There were little differences between the two modes of administration in effecting a decrease in the uptake of131I. In view of these similarities of results, there seems to be some questions as to whether these substances elicit their effects on the thyroid gland through nuclei of the central nervous system or via other channels such as the pineal gland. |
| Databáze: | OpenAIRE |
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