Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults
| Autor: | Nicholas Dietz, Teresa E. Seeman, Richard G. Olmstead, Dominique Piber, Tuff Witarama, Michael R. Irwin, Joshua Hyong-Jin Cho, Christian Perez, Elizabeth C. Breen, Steve W. Cole |
|---|---|
| Přispěvatelé: | Le Couteur, David |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_treatment Systemic inflammation NF-κB 0302 clinical medicine 80 and over STAT5 Transcription Factor 2.1 Biological and endogenous factors Medicine STAT1 Aetiology Cancer Aged 80 and over biology Age Factors NF-kappa B Middle Aged STAT signaling C-Reactive Protein STAT1 Transcription Factor Cytokine The Journal of Gerontology: Biological Sciences Cytokines Female Tumor necrosis factor alpha Independent Living Inflammation Mediators medicine.symptom Signal Transduction STAT3 Transcription Factor medicine.medical_specialty Clinical Sciences Inflammation Risk Assessment C-reactive protein Proinflammatory cytokine 03 medical and health sciences Internal medicine Humans Interleukin 6 Aged Proinflammatory cytokines Tumor Necrosis Factor-alpha business.industry Tumor Suppressor Proteins Inflammatory and immune system Cross-Sectional Studies 030104 developmental biology Endocrinology Gene Expression Regulation Multivariate Analysis Linear Models biology.protein Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences, vol 74, iss 11 J Gerontol A Biol Sci Med Sci |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glz130 |
| Popis: | Systemic inflammation is associated with increasing age. Yet, there are limited data about the association between age and systemic inflammation within older adults, and whether older age is also associated with cellular and nuclear signaling markers of inflammation. In community-dwelling older adults (N = 262, 60–88 years), systemic levels of C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptor II; levels of toll-like receptor-4–stimulated monocytic production of interleukin-6 and tumor necrosis factor α; and resting nuclear levels of activated nuclear factor kappa B and signal transducer and activator of transcription (STAT1, STAT3, STAT5) were evaluated. Adjusting for demographic and clinical factors, multivariate linear regression tested the association between age and each inflammatory marker. Age was positively associated with increased levels of interleukin-6 and soluble tumor necrosis factor receptor II (p’s < .05) and with increases in STAT1, STAT3, and STAT5 activation (p’s < .05). However, no relationship was found between age and C-reactive protein, toll-like receptor-4–stimulated interleukin-6/tumor necrosis factor alpha α production, or nuclear factor kappa B. Within a community-dwelling sample of older adults, older age is associated with increases in STAT activation, along with increases of systemic inflammatory cytokines. In older adults, heterogeneity in age-related increases in inflammatory disease risk may be related to individual variability in inflammation. |
| Databáze: | OpenAIRE |
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