31P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results
| Autor: | Benjamin Bender, Christian Mirkes, K. Buckenmaier, G Chadzynski, Klaus Scheffler, Gunamony Shajan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Materials science Proton Proton Magnetic Resonance Spectroscopy Biophysics Signal-To-Noise Ratio 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Flip angle Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Radiological and Ultrasound Technology Brain Neoplasms Phantoms Imaging Dipole array Healthy subjects Magnetic resonance spectroscopic imaging Brain Cell Differentiation Phosphorus Human brain Equipment Design Hydrogen-Ion Concentration Models Theoretical Magnetic Resonance Imaging Healthy Volunteers medicine.anatomical_structure Repetition Time Electromagnetic coil Positron-Emission Tomography Female 030217 neurology & neurosurgery |
| Zdroj: | Magnetic Resonance Materials in Physics, Biology and Medicine |
| Popis: | Objective Investigation of the feasibility and performance of phosphorus (31P) magnetic resonance spectroscopic imaging (MRSI) at 9.4 T with a three-layered phosphorus/proton coil in human normal brain tissue and tumor. Materials and methods A multi-channel 31P coil was designed to enable MRSI of the entire human brain. The performance of the coil was evaluated by means of electromagnetic field simulations and actual measurements. A 3D chemical shift imaging approach with a variable repetition time and flip angle was used to increase the achievable signal-to-noise ratio of the acquired 31P spectra. The impact of the resulting k-space modulation was investigated by simulations. Three tumor patients and three healthy volunteers were scanned and differences between spectra from healthy and cancerous tissue were evaluated qualitatively. Results The high sensitivity provided by the 27-channel 31P coil allowed acquiring CSI data in 22 min with a nominal voxel size of 15 × 15 × 15 mm3. Shimming and anatomical localization could be performed with the integrated four-channel proton dipole array. The amplitudes of the phosphodiesters and phosphoethanolamine appeared reduced in tumorous tissue for all three patients. A neutral or slightly alkaline pH was measured within the brain lesions. Conclusion These initial results demonstrate that 31P 3D CSI is feasible at 9.4 T and could be performed successfully in healthy subjects and tumor patients in under 30 min. |
| Databáze: | OpenAIRE |
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