Dural and Multiple Brain Metastases From Basaloid Nasopharyngeal Carcinoma: Case Report and Literature Review
Autor: | Yaping Zhang, Guiyan Han, Peiyan Qin, Furong Hao, Xiaotao Geng |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty basaloid nasopharyngeal carcinoma medicine.medical_treatment Case Report Nasal congestion chemotherapy 03 medical and health sciences 0302 clinical medicine Biopsy Medicine brain metastasis Basaloid Squamous Cell Carcinoma dural metastasis radiotherapy RC254-282 medicine.diagnostic_test business.industry basaloid squamous cell carcinoma nasopharyngeal carcinoma Head and neck cancer Soft tissue Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Radiation therapy 030104 developmental biology Nasopharyngeal carcinoma Oncology 030220 oncology & carcinogenesis Radiology immunotherapy medicine.symptom business Brain metastasis |
Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
Popis: | BackgroundNasopharyngeal carcinoma is an endemic head and neck cancer in Southern China. The common metastases organs involve bone, lung, and liver. Metastases in the dura and at multiple locations in the brain after a diagnosis of nasopharyngeal carcinoma are extremely rare.Case PresentationWe present a case of a 66-year-old man who initially complained of nasal congestion, epistaxis, and hearing impairment. The biopsy of the nasopharynx lesion showed basaloid squamous cell carcinoma. Eight months after conventional therapy, the patient was admitted to our hospital again with the complaint of a headache. A PET/CT scan was performed, revealing multiple metastases. A biopsy of subcutaneous soft tissue from the right upper arm was consistent with the previous biopsy. Palliative chemotherapy was administered. Thereafter, the patient had sudden dysfunction of the right side of the body. MRI demonstrated dural and multiple brain metastases. The therapeutic regimen then consisted of whole-brain radiotherapy, anti-angiogenesis therapy, and immunotherapy.ConclusionsThis case highlights the diagnosis and treatment of uncommon metastases of nasopharyngeal carcinoma. Clinicians should remain vigilant for metastases during the treatment and follow-up periods. |
Databáze: | OpenAIRE |
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