Retinyl acetate-loaded nanoparticles: dermal penetration and release of the retinyl acetate
| Autor: | Sunatda Arayachukeat, Thapakorn Tree-Udom, Supason Wanichwecharungruang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Retinyl Esters
Stereochemistry Ultraviolet Rays Chemistry Pharmaceutical Drug Compounding Skin Absorption Pharmaceutical Science Retinyl acetate Administration Cutaneous Polyethylene Glycols chemistry.chemical_compound Mice Dermis Ethyl cellulose Drug Stability medicine Animals Nanotechnology Technology Pharmaceutical Microparticle Cellulose Vitamin A Skin Chitosan Drug Carriers Chromatography Microscopy Confocal Photolysis Hair follicle Kinetics medicine.anatomical_structure chemistry Solubility Liberation Nanoparticles Diterpenes Drug carrier Ethylene glycol |
| Zdroj: | International journal of pharmaceutics. 404(1-2) |
| ISSN: | 1873-3476 |
| Popis: | Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC, whilst EC encapsulation gave some improved stability in water but showed no improved photostability. Ex vivo application of free RA and the RA-loaded PCPLC NPs onto the surface of the freshly excised skin from a baby mouse indicated a significantly slower skin absorption rate for the encapsulated RA. However, 100% retention of the encapsulated RA in the skin tissue was observed after 24h. Confocal fluorescent analysis of the skin pieces applied with the RA-loaded PCPLC NPs indicated likely entry and accumulation of the PCPLC NPs and RA at the hair follicles. Release of RA from the PCPLC NP carriers was confirmed through the detection of an increasingly higher RA/PCPLC fluorescent signal ratio deeper into the dermis and away from the hair follicles. |
| Databáze: | OpenAIRE |
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