Mechanisms regulating endothelial cell barrier function
| Autor: | Troy Stevens, D. Michael Shasby, Joe G.N. Garcia, Jahar Bhattacharya, Asrar B. Malik |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
Endothelium Physiology Inflammation Vascular permeability Biology Capillary Permeability Physiology (medical) medicine Cyclic AMP Animals Humans Myosin-Light-Chain Kinase Barrier function Cell Biology Cell biology Endothelial stem cell medicine.anatomical_structure Biochemistry Calcium Endothelium Vascular medicine.symptom Signal transduction Intracellular Blood vessel Signal Transduction |
| Zdroj: | American journal of physiology. Lung cellular and molecular physiology. 279(3) |
| ISSN: | 1040-0605 |
| Popis: | Endothelium forms a physical barrier that separates blood from tissue. Communication between blood and tissue occurs through the delivery of molecules and circulating substances across the endothelial barrier by directed transport either through or between cells. Inflammation promotes macromolecular transport by decreasing cell-cell and cell-matrix adhesion and increasing centripetally directed tension, resulting in the formation of intercellular gaps. Inflammation may also increase the selected transport of macromolecules through cells. Significant progress has been made in understanding the molecular and cellular mechanisms that account for constitutive endothelial cell barrier function and also the mechanisms activated during inflammation that reduce barrier function. Current concepts of mechanisms regulating endothelial cell barrier function were presented in a symposium at the 2000 Experimental Biology Conference and are reviewed here. |
| Databáze: | OpenAIRE |
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