Direct Cell Death Induced by CD20 Monoclonal Antibodies on B Cell Lymphoma Cells Revealed by New Protocols of Analysis
Autor: | Michael Constantinides, Alexis Fayd’herbe De Maudave, Marie Potier-Cartereau, Mauricio Campos-Mora, Guillaume Cartron, Martin Villalba |
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Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Cancers Volume 15 Issue 4 Pages: 1109 |
ISSN: | 2072-6694 |
Popis: | CD20 monoclonal antibodies (mAbs) eliminate B cells in several clinical contexts. At least two of these Abs, obinutuzumab (OBI) and rituximab (RTX), induce quick elimination of targets and put cancer patients at risk of tumor lysis syndrome (TLS) within 12–24 h of the first dose. The mechanisms of killing can require the recruiting of effector mechanisms from the patient’s immune system, but they can induce direct killing as well. This can be more rapid than recruiting cellular effectors and/or complement. We showed here that OBI and RTX induce quick ( |
Databáze: | OpenAIRE |
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