Direct Cell Death Induced by CD20 Monoclonal Antibodies on B Cell Lymphoma Cells Revealed by New Protocols of Analysis

Autor:	Michael Constantinides, Alexis Fayd’herbe De Maudave, Marie Potier-Cartereau, Mauricio Campos-Mora, Guillaume Cartron, Martin Villalba
Rok vydání:	2023
Předmět:	obinutuzumab Cancer Research rituximab Oncology direct killing LLC CD20 mAbs B cell lymphoma
Zdroj:	Cancers Volume 15 Issue 4 Pages: 1109
ISSN:	2072-6694
Popis:	CD20 monoclonal antibodies (mAbs) eliminate B cells in several clinical contexts. At least two of these Abs, obinutuzumab (OBI) and rituximab (RTX), induce quick elimination of targets and put cancer patients at risk of tumor lysis syndrome (TLS) within 12–24 h of the first dose. The mechanisms of killing can require the recruiting of effector mechanisms from the patient’s immune system, but they can induce direct killing as well. This can be more rapid than recruiting cellular effectors and/or complement. We showed here that OBI and RTX induce quick (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08690b61b43de90a7a88117ce9a44ab0 https://doi.org/10.3390/cancers15041109 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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