Hepatic arterial chemotherapy: role of angiography
| Autor: | Kyung J. Cho, F Doenz, David M. Williams, James C. Andrews, G E Guy |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Percutaneous Colorectal cancer medicine.medical_treatment Serum albumin Hemodynamics Antineoplastic Agents Catheterization Hepatic Artery medicine Humans Infusions Intra-Arterial Radiology Nuclear Medicine and imaging Infusion Pumps Chemotherapy biology medicine.diagnostic_test business.industry Liver Neoplasms medicine.disease Radiography Catheter Angiography biology.protein Radiology business Perfusion Liver Circulation |
| Zdroj: | Radiology. 173(3) |
| ISSN: | 0033-8419 |
| Popis: | Hepatic arterial infusion chemotherapy increases the hepatic concentration of chemotherapeutic agents without increasing systemic toxicity. Both percutaneous (most commonly left transbrachial) and surgical approaches are currently used for infusion catheter placement. Surgical catheter and pump placement has proved to be a reliable means of delivering drugs to the liver and has been commonly used for hepatic arterial chemotherapy for metastatic colorectal carcinoma. Meticulous angiographic evaluation of the hepatic vascular anatomy, its variations, and hemodynamics is necessary for correct catheter placement to achieve total liver perfusion without significant extrahepatic perfusion. Satisfactory hepatic perfusion should be documented before drug infusion. Hepatic arterial radionuclide flow imaging with technetium-99m-labeled macroaggregated serum albumin remains the most reliable means of assessing hepatic perfusion following catheter placement. Transcatheter techniques have been used to facilitate catheter placement, to prevent gastrointestinal drug toxicity, and to correct unsatisfactory perfusion following surgical catheter placement. |
| Databáze: | OpenAIRE |
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