Quantitative gas chromatographic determination of perfluorooctanoic acid as the benzyl ester in plasma and urine
| Autor: | Osmo Rämö, Pekka Peura, Markku Ylinen, Hannu Hanhijärvi |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Detection limit
chemistry.chemical_classification Fluorocarbons Chromatography Chromatography Gas Chemistry Health Toxicology and Mutagenesis General Medicine Urine Alkylation Toxicology Pollution chemistry.chemical_compound Dogs Benzyl bromide Bromide Perfluorooctanoic acid Animals Gas chromatography Counterion Caprylates |
| Zdroj: | Archives of environmental contamination and toxicology. 14(6) |
| ISSN: | 0090-4341 |
| Popis: | A method is presented for the quantitative determination of perfluorooctanoic acid in plasma and urine. The acid was esterified by an extractive alkylation method using tetrabutylammonium ion as the counter ion and benzyl bromide as the alkylating agent. Quantitation was made by gas chromatography. Typical values for precision obtained in the determination of 5 μg/ml of perfluorooctanoic acid in plasma and urine were 3.3% (S.D. N=6) and 3.0% (S.D. N=6), respectively. The limit of detection was 1 ng (2.4 pmol). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink