Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis
| Autor: | Maria Carmela Lorito, Alessandro Palermo, Rosalia Arsena, Francesco Vaccaro, Santina Cottone, R. Riccobene, Marco Guarneri, Giovanni Cerasola, Giuseppe Mulè |
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| Přispěvatelé: | Palermo, A, Mule', G, Guarneri, M, Arsena, R, Riccobene, R, Lorito, MC, Vaccaro, F, Cerasola, G, Cottone, S |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Parathyroid hormone vitamin D deficiency End stage renal disease Renal Dialysis Internal medicine medicine Humans Hypocalcaemia chronic kidney disease dialysis end-stage renal disease endothelin-1 parathyroid hormone Aged Parathyroid adenoma Endothelin-1 business.industry General Medicine Middle Aged medicine.disease Endothelin 1 Endocrinology Parathyroid Hormone Nephrology Kidney Failure Chronic Regression Analysis Parathyroid hormone secretion Female Secondary hyperparathyroidism business |
| Zdroj: | Nephrology. 13:467-471 |
| ISSN: | 1440-1797 1320-5358 |
| DOI: | 10.1111/j.1440-1797.2008.00972.x |
| Popis: | SUMMARY: Aim: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients. Methods: Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded. Results: Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone (P < 0.04) The multiple regression analysis, carried out considering parathyroid hormone as a dependent variable, and including age, sex, blood pressure, calcium ¥ phosphorus product, and endothelin-1, demonstrated that the independent correlates of parathyroid hormone were endothelin-1 ( b=- 0.276; P = 0.015), and calcium ¥ phosphorus product ( b= 0.417; P < 0.0001). Conclusion: For the first time in vivo, we demonstrated an inverse independent relationship between endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism remains to be elucidated. |
| Databáze: | OpenAIRE |
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