Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias
| Autor: | Giorgio Sandrini, Francesco Pierelli, Roberto De Icco, Armando Perrotta, Vincenzo Parisi, Anna Ambrosini, Mariano Serrao, Gianluca Coppola, Maria Grazia Anastasio, Maurizio Evangelista |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pain nociceptive blink reflex Stimulation Audiology 03 medical and health sciences 0302 clinical medicine cluster headache habituation paroxysmal hemicrania neurology neurology (clinical) anesthesiology and Pain Medicine Settore MED/41 - ANESTESIOLOGIA Humans Medicine Paroxysmal Hemicrania Corneal reflex Habituation Habituation Psychophysiologic business.industry Cluster headache Erythropoietin-producing hepatocellular (Eph) receptor Middle Aged medicine.disease Electric Stimulation Trigeminal Autonomic Cephalalgias Settore MED/26 - NEUROLOGIA 030104 developmental biology Anesthesiology and Pain Medicine Nociception Neurology Case-Control Studies Female Neurology (clinical) Trigeminal autonomic cephalalgia business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Pain. 19:1040-1048 |
| ISSN: | 1526-5900 |
| DOI: | 10.1016/j.jpain.2018.03.015 |
| Popis: | We investigated whether the stimulation frequency (SF), the pain phases, and different diagnoses of trigeminal autonomic cephalalgias (TACs) may influence the habituation to pain. We studied the habituation of the nociceptive blink reflex R2 responses at different SFs (.05, .1, .2, .3, .5, and 1 Hz), in 28 episodic cluster headache (ECH) patients, 16 during and 12 outside the bout; they were compared with 16 episodic paroxysmal hemicrania (EPH) during the bout and 21 healthy subjects. We delivered 26 electrical stimuli and subdivided stimuli 2 to 26 in 5 blocks of 5 responses for each SF. Habituation values for each SF were expressed as the percentages of the mean area value of second through fifth blocks with respect to the first one. A significant lower mean percentage decrease of the R2 area across all blocks was found at .2 to 1 Hz SF during ECH, outside of the ECH, and EPH compared with healthy subjects. We showed a common frequency-dependent deficit of habituation of trigeminal nociceptive responses at higher SFs in ECH and EPH patients, independently from the disease phase. This abnormal temporal pattern of pain processing may suggest a trait-dependent dysfunction of some underlying pain-related subcortical structures, rather than a state-dependent functional abnormality due to the recurrence of the headache attacks during the active period. Perspective TACs showed a frequency-related defective habituation of nociceptive trigeminal responses at the higher SFs, irrespectively of the diagnosis and/or the disease phase. We showed that the clinical similarities in the different subtypes of TACs are in parallel with a trait-dependent dysfunction in pain processing. |
| Databáze: | OpenAIRE |
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