Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark, 1996-2016
| Autor: | Emil L. Fosbøl, Christina Kruuse, Naja Emborg Vinding, Lars Køber, Adelina Yafasova, Christian Torp-Pedersen, Charlotte Andersson, Mia N. Christiansen, Jawad H. Butt, Gunnar Gislason, Søren Paaske Johnsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Denmark Comorbidity Brain Ischemia Cohort Studies symbols.namesake Young Adult Sex Factors Risk Factors Internal medicine medicine Odds Ratio Prevalence Humans Poisson regression Poisson Distribution Registries Aged Proportional Hazards Models Aged 80 and over Proportional hazards model business.industry Incidence (epidemiology) Incidence Hazard ratio Age Factors Odds ratio Middle Aged medicine.disease Confidence interval Stroke Logistic Models symbols Regression Analysis Female Neurology (clinical) business Cohort study |
| Zdroj: | Yafasova, A, Fosbøl, E L, Christiansen, M N, Vinding, N E, Andersson, C, Kruuse, C, Johnsen, S P, Gislason, G H, Torp-Pedersen, C, Køber, L & Butt, J H 2020, ' Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark, 1996-2016 ', Neurology, vol. 95, no. 17, pp. e2343-e2353 . https://doi.org/10.1212/WNL.0000000000010647 Yafasova, A, Fosbøl, E L, Christiansen, M N, Vinding, N E, Andersson, C, Kruuse, C, Johnsen, S P, Gislason, G H, Torp-Pedersen, C, Køber, L & Butt, J H 2020, ' Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark (1996-2016) ', Neurology, vol. 95, no. 17, pp. e2343-e2353 . https://doi.org/10.1212/WNL.0000000000010647 |
| Popis: | ObjectiveTo examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design.MethodsIn this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic stroke between 1996 and 2016 were identified through Danish nationwide registries. We calculated annual age-standardized incidence rates and absolute 30-day and 1-year mortality risks. Furthermore, we calculated annual incidence rate ratios using Poisson regression, odds ratios for 30-day mortality using logistic regression, and hazard ratios for 1-year mortality using Cox regression.ResultsThe overall age-standardized incidence rates of ischemic stroke per 1,000 person-years increased from 1996 (2.70 [95% confidence interval [CI] 2.65–2.76]) to 2002 (3.25 [95% CI 3.20–3.31]) and then gradually decreased to below the initial level until 2016 (1.99 [95% CI 1.95–2.02]). Men had higher incidence rates than women in all age groups except 18 to 34 and ≥85 years. Absolute mortality risk decreased between 1996 and 2016 (30-day mortality from 17.1% to 7.6% and 1-year mortality from 30.9% to 17.3%). Women between 55 and 64 and ≥85 years of age had higher mortality than men. Similar trends were observed for all analyses after multivariable adjustment. The prevalence of atrial fibrillation, hypertension, diabetes mellitus, and use of lipid-lowering medication increased during the study period.ConclusionsThe age-standardized incidence of first-time hospitalization for ischemic stroke increased from 1996 to 2002 and then gradually decreased to below the initial level until 2016. Absolute 30-day and 1-year mortality risks decreased between 1996 and 2016. These findings correspond to increased stroke prevention awareness and introduction of new treatments during the study period. |
| Databáze: | OpenAIRE |
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