Imbalances in the disposition of estrogen and naphthalene in breast cancer patients: a potential biomarker of breast cancer risk
| Autor: | Kuo-Juei Lin, Yi-Lun Liao, Dar-Ren Chen, Po-Hsiung Lin, Yu-Fen Wang, Wei-Chung Hsieh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Risk 0301 basic medicine medicine.medical_specialty medicine.drug_class Serum albumin lcsh:Medicine Breast Neoplasms Naphthalenes medicine.disease_cause Article Gas Chromatography-Mass Spectrometry Tumour biomarkers Young Adult 03 medical and health sciences Breast cancer 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Young adult lcsh:Science Aged Multidisciplinary biology business.industry lcsh:R Case-control study Cancer Estrogens Middle Aged Prognosis medicine.disease Quinone 030104 developmental biology Endocrinology Risk factors Estrogen Case-Control Studies 030220 oncology & carcinogenesis biology.protein Female lcsh:Q Disease Susceptibility Carcinogenesis business |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Elevation of naphthoquinones and estrogen quinones, which are reactive metabolites of naphthalene and estrogen, is thought to be an important indicator of naphthalene- and estrogen-induced carcinogenesis. We compared background levels of naphthalene and estrogen quinone-derived adducts in serum albumin (Alb) from 143 women with breast cancer and 119 healthy controls. Cysteinyl adducts of naphthoquinones, including 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ), and estrogen quinones, including estrogen-2,3-quinones (E2-2,3-Q) and estrogen-3,4-quinones (E2-3,4-Q), were characterized after adduct cleavage. Levels of estrogen quinones and naphthoquinones were positively correlated in healthy controls, but not in breast cancer patients (p 2-3,4-Q were elevated by two- to ten-fold in cancer patients (p 2-3,4-Q-2-S-Alb to (E2-2,3-Q-4-S-Alb plus E2-3,4-Q-2-S-Alb) in patients and controls. These two groups were separable using albumin adducts of estrogen quinones and naphthoquinones, with 99.6% overall correct classification rate (overall accuracy). The findings of this study suggest that differences in the disposition of estrogen and naphthalene, and the subsequent elevation of cumulative E2-3,4-Q and 1,2-NPQ may serve as biomarkers of breast cancer risk. |
| Databáze: | OpenAIRE |
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