Increased Dephospho-uncarboxylated Matrix Gla-Protein Is Associated With Lower Axial Skeletal Muscle Mass in Patients With Hypertension

Autor: Mahesh K Vidula, Scott Akers, Bilal A Ansari, Jessica Kim, Anupam A Kumar, Dheera Tamvada, Vaibhav Satija, Jagan Mohan-Rao Vanjarapu, Qasim Jehangir, Caroline Magro, Chenao Qian, Julio A Chirinos
Rok vydání: 2022
Předmět:
Zdroj: Am J Hypertens
ISSN: 1941-7225
0895-7061
DOI: 10.1093/ajh/hpab190
Popis: Background Matrix Gla-protein (MGP) is a well-established inhibitor of vascular calcification that is activated by vitamin K-dependent carboxylation. In the setting of vitamin K2 deficiency, dephospho-uncarboxylated MGP (dpucMGP) levels increase, and have been associated with large artery stiffening. Vitamin K2 is also a mitochondrial electron carrier in muscle, but the relationship of vitamin K2 deficiency and dpucMGP with muscle mass is not well understood. We therefore aimed to examine the association of vitamin K2 deficiency and dpucMGP with skeletal muscle mass in patients with hypertension. Methods We studied 155 hypertensive adults without heart failure. Axial skeletal muscle mass was measured using magnetic resonance imaging from axial steady-state free precession images. DpucMGP was measured with ELISA. Carotid–femoral pulse wave velocity (CF-PWV) was measured from high-fidelity arterial tonometry recordings. Results We found an inverse relationship between dpucMGP levels and axial muscle mass, with progressively rising dpucMGP levels correlating with decreasing axial muscle mass. In an unadjusted linear regression model, correlates of dpucMGP included axial skeletal muscle area factor (β = −0.32; P < 0.0001) and CF-PWV (β = 0.31; P = 0.0008). In adjusted analyses, independent correlates of dpucMGP included axial skeletal muscle area factor (β = −0.30; P = 0.0003) and CF-PWV (β = 0.20; P = 0.019). Conclusions In hypertensive adults, dpucMGP is independently associated with lower axial muscle mass, in addition to increased large artery stiffness. Further studies are required to investigate the role of vitamin K supplementation in this population.
Databáze: OpenAIRE
Externí odkaz: