Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles
| Autor: | Bert De Roo, Jean-Pierre Locquet, Annelii Ny, Peter de Witte, Xuan-Bac Nguyen, Angela Kecskés, Peter Hoet, Duc-Hung Pham, Mattias Vervaele, Hanne Vriens, Daniëlle Copmans |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Embryo
Nonmammalian animal structures Endpoint Determination 02 engineering and technology 010501 environmental sciences 01 natural sciences Article Silica nanoparticles In vivo medicine Animals Particle Size Toxicity profile Zebrafish 0105 earth and related environmental sciences Multidisciplinary Behavior Animal biology Chemistry Hatching Neurotoxicity Heart respiratory system Silicon Dioxide 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Cell biology Nanotoxicology Toxicity Nanoparticles Chemical and Drug Induced Liver Injury 0210 nano-technology |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep37145 |
| Popis: | Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity profile is poorly characterized. In this study, we investigated the toxicity of silica nanoparticles with diameters 20, 50 and 80 nm using an in vivo zebrafish platform that analyzes multiple endpoints related to developmental, cardio-, hepato-, and neurotoxicity. Results show that except for an acceleration in hatching time and alterations in the behavior of zebrafish embryos/larvae, silica NPs did not elicit any developmental defects, nor any cardio- and hepatotoxicity. The behavioral alterations were consistent for both embryonic photomotor and larval locomotor response and were dependent on the concentration and the size of silica NPs. As embryos and larvae exhibited a normal touch response and early hatching did not affect larval locomotor response, the behavior changes observed are most likely the consequence of modified neuroactivity. Overall, our results suggest that silica NPs do not cause any developmental, cardio- or hepatotoxicity, but they pose a potential risk for the neurobehavioral system. ispartof: Scientific Reports vol:6 issue:1 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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