Action of Thionyl Chloride on Carboxylic Acids in Presence of Pyridine

Autor:	John A. Mills, J. P. E. Human
Rok vydání:	1946
Předmět:	Multidisciplinary Pyridines Carboxylic Acids Sulfur Oxides Medicinal chemistry Chloride Catalytic effect chemistry.chemical_compound Thionyl chloride chemistry Yield (chemistry) Pyridine medicine Acids medicine.drug
Zdroj:	Nature. 158:877-877
ISSN:	1476-4687 0028-0836
DOI:	10.1038/158877a0
Popis:	THE catalytic effect of small amounts of pyridine in the reaction between thionyl chloride and carboxylic acids is well known; Carre and Libermann1 have shown further that it is of great advantage to use equimolar quantities of acid, pyridine, and thionyl chloride, the acid chloride then being formed rapidly at lower temperatures, in high yield. This convenient method apparently has not been very widely used, and instructions for making acid chlorides generally call for the use of excess thionyl chloride and ‘a few drops’ of pyridine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08605065ab838769763e6fdf27bc77d0 https://doi.org/10.1038/158877a0 Zobrazit plný text záznamu