Autoantibodies in childhood connective tissue diseases and in normal children
| Autor: | M Mason, K M Goel, R N MacSween, R A Shanks, K Whaley |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent IgA Vasculitis Anti-nuclear antibody Thyroid Gland Fluorescent Antibody Technique Connective tissue Gastroenterology Dermatomyositis Serology Rheumatoid Factor Internal medicine medicine Humans Lupus Erythematosus Systemic Rheumatoid factor Child Autoantibodies Scleroderma Systemic business.industry Stomach Thyroid Collagen Diseases Infant Newborn Autoantibody Infant medicine.disease Arthritis Juvenile medicine.anatomical_structure Connective Tissue Antibodies Antinuclear Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Juvenile rheumatoid arthritis Research Article |
| Zdroj: | Archives of Disease in Childhood. 50:419-423 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.50.6.419 |
| Popis: | The prevalence of nine serum autoantibodies has been studied in 117 children with various connective tissue disorders and in 134 normal controls. In juvenile rheumatoid arthritis rheumatoid factor was present in 5%, and antinuclear factor in 4%, compared with an incidence of 4% and 0% respectively in controls. In Henoch-Schönlein purpura there was little evidence of associated autoimmune disorder. Gastric parietal cell and thyroid microsomal antibodies were found in 9% and 10% of our control population, but the significance of this is not clear. It is concluded that in children the presence or absence of autoantibodies as diagnostic criteria should be interpreted with the greatest caution. |
| Databáze: | OpenAIRE |
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