Clinical significance of acquired activated protein C resistance in patients with systemic lupus erythematosus
| Autor: | Juan Carlos Reverter, Ricard Cervera, F. J. Muñoz-Rodriguez, Josep Font, Gerard Espinosa, Francisco Carmona, Juan Balasch, Dolors Tàssies, Antonio Ordinas, Miguel Ingelmo |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Adolescent 030204 cardiovascular system & hematology Protein S 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Pregnancy medicine Factor V Leiden Prevalence Humans Lupus Erythematosus Systemic Activated Protein C Resistance Aged 030203 arthritis & rheumatology Lupus anticoagulant Lupus erythematosus biology business.industry Factor V Thrombosis Middle Aged medicine.disease Abortion Spontaneous Venous thrombosis Immunology biology.protein Antibodies Antiphospholipid Female Activated protein C resistance business Protein C medicine.drug |
| Zdroj: | Lupus. 11(11) |
| ISSN: | 0961-2033 |
| Popis: | Antiphospholipid antibodies (aPL) may induce acquired activated protein C resistance (acquired APCR). The role of acquired APCR in patients with systemic lupus erythematosus (SLE) is not well known. To evaluate the prevalenceof acquiredAPCR and its associationwith clinical manifestations we studied 103 consecutive SLE patients and 103 matched controls. APCR in the undiluted test and after dilution in factor V deficient plasma, factor V Leiden, protein C and S, lupus anticoagulant,and anti-cardiolipin,anti-β2-glycoprotein I and anti-prothrombin antibodies were determined. Factor V Leiden was found in 4% in both patients and controls.The prevalenceof acquiredAPCR was 22% for the undiluted assay and 17% in the diluted test. In SLE patients,acquired APCR was associated with aPL (39 vs 13% in undiluted assay, P=0.007; and 33 vs 7% in the diluted test, P=0.001). Arterial thromboses were found in 24% of patients with acquired APCR and in 6% of patients without (P=0.04). However, no relationship was found with venous thrombosis. Acquired APCR was also associated with pregnancy losses: miscarriages in 70% of women with acquired APCR vs 32% in those without (P=0.03). Thus, in SLE patients acquired APCR seems to be associated with increased prevalence of arterial thrombosis and pregnancy losses. |
| Databáze: | OpenAIRE |
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