[Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives]
| Autor: | O. N. Krivoshapko, A. A. Klimovich, A. M. Popov, Artyukov Aleksandr A |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Hyperlipidemias Depsides General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Sulfation Hyperlipidemia medicine Cinnamates Animals Humans Luteolin Chemistry Rosmarinic acid Lipid metabolism Biological activity General Medicine Carbohydrate medicine.disease Disease Models Animal 030104 developmental biology Biochemistry Diabetes Mellitus Type 2 |
| Zdroj: | Biomeditsinskaia khimiia. 62(1) |
| ISSN: | 2310-6972 |
| Popis: | The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.Obobshcheny rezul'taty nedavnikh éksperimental'nykh issledovaniĭ biologicheskoĭ aktivnosti i mekhanizmov lechebnogo deĭstviia rozmarinovoĭ kisloty, liuteolina i ego sul'fatirovannykh proizvodnykh pri zabolevaniiakh, sviazannykh s narusheniem uglevodnogo i lipidnogo obmena. Osoboe vnimanie udeleno dannym, pokazyvaiushchim vysokiĭ terapevticheskiĭ potentsial étikh soedineniĭ pri profilakticheskom i lechebnom primenenii pri éksperimental'nom sakharnom diabete 2-go tipa i giperlipidemii. Na osnovanii analiza poluchennykh nami rezul'tatov i literaturnykh dannykh predlozheny predpolagaemye mekhanizmy lechebnogo deĭstviia rozmarinovoĭ kisloty, liuteolina i ego sul'fatirovannykh proizvodnykh. |
| Databáze: | OpenAIRE |
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