Lymphocyte suppression associated with alpha globulin changes in cellular immunity
| Autor: | Denis R. Burger, R. Mark Vetto, David P. Lilley |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Cellular immunity Lymphocyte Guinea Pigs Immunology Lymphocyte Activation Tritium In vivo Lectins Internal medicine Alpha-Globulins Concanavalin A medicine Animals Alpha globulin Nitrobenzenes Sensitization Skin Tests Whole blood Immunosuppression Therapy biology Tuberculin Test Pokeweed mitogen Electrophoresis Disc Endocrinology medicine.anatomical_structure biology.protein Immunization Mitogens Thymidine |
| Zdroj: | Cellular Immunology. 10:432-441 |
| ISSN: | 0008-8749 |
| Popis: | Sensitization of guinea pigs to 2,4-dinitrofluorobenzene is accompanied by increases in alpha globulins determined electrophoretically. During sensitization, lymphocyte responses were measured in vitro by mitogen induced 3H-thymidine uptake in whole blood cultures and in vivo by dermal skin reactivity. Following 5 days of dinitrofluorobenzene sensitization alpha globulins were elevated and lymphocyte transformation to phytohemagglutinin, pokeweed mitogen, and concanavalin A was significantly suppressed. When the alpha globulins returned to normal levels following sensitization, lymphocyte responses returned to pretreatment values. Antigen induced lymphocyte responsiveness was also suppressed concomitant with elevations in alpha globulins. Tuberculin sensitive guinea pigs responded poorly to PPD in vitro and in vivo during DNFB sensitization. It is suggested that increases in alpha globulins detected during the development of cellular immunity are associated with immunosuppression. |
| Databáze: | OpenAIRE |
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