Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea
| Autor: | Sook-In, Jung, Jong Hee, Shin, Jae-Hoon, Song, Kyong Ran, Peck, Kyungwon, Lee, Mi-Na, Kim, Hyun Ha, Chang, Chi Sook, Moon, Sang Yop, Shin |
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| Rok vydání: | 2010 |
| Předmět: |
Antifungal Agents
Echinocandin Microbial Sensitivity Tests Candida parapsilosis Microbiology chemistry.chemical_compound Drug Resistance Fungal Republic of Korea medicine Humans Candida albicans Candida biology Candida glabrata Broth microdilution Micafungin Candidiasis General Medicine bacterial infections and mycoses biology.organism_classification Infectious Diseases chemistry Population Surveillance Caspofungin Fungemia Fluconazole medicine.drug |
| Zdroj: | Medical mycology. 48(4) |
| ISSN: | 1460-2709 |
| Popis: | Multicenter data on in vitro susceptibility of Candida bloodstream isolates to echinocandin antifungal agents is still lacking in South Korea. We performed a prospective multicenter study to determine the species distribution of Candida bloodstream isolates and their susceptibility to five antifungal agents, including caspofungin and micafungin. A total of 639 isolates were collected from 20 tertiary hospitals between September 2006 and August 2007. Antifungal susceptibilities were determined through the use of the CLSI broth microdilution method M27-A3. The overall species distribution was as follows; Candida albicans (38%), Candida parapsilosis (26%), Candia tropicalis (20%), Candida glabrata (11%), and miscellaneous Candida species (5%). Although C. parapsilosis and miscellaneous Candida species were less susceptible to both echinocandins, all 639 isolates were susceptible to both caspofungin and micafungin (MIC,or= 2 microg/ml). Nearly all isolates (99.7%) had a MICor= 1 microg/ml to amphotericin B. Resistance to fluconazole and voriconazole was found in 0.8% and 0.3%, respectively, among all Candida isolates, with C. glabrata and C. krusei isolates displaying the greatest level of resistance. This is the largest multicenter candidemia study conducted in South Korea and shows that non-C. albicans Candida species, including C. parapsilosis, constitutes over 60% of all Candida species isolates recovered from the bloodstream. In addition, the rates of resistance to all five antifungals, including two echinocandins, are still low among bloodstream isolates in South Korea. |
| Databáze: | OpenAIRE |
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