Separation and Quantitation of Possible Degradation Products of Procarbazine Hydrochloride in Its Dosage Form

Autor:	Gary L. Burce, Judy P. Boehlert
Rok vydání:	1978
Předmět:	Chromatography Cinnamyl alcohol Pharmaceutical Science Capsules Procarbazine Dosage form chemistry.chemical_compound Drug Stability chemistry Methods medicine Degradation (geology) Procarbazine Hydrochloride Chromatography High Pressure Liquid medicine.drug
Zdroj:	Journal of Pharmaceutical Sciences. 67:424-426
ISSN:	0022-3549
DOI:	10.1002/jps.2600670345
Popis:	A stability-indicating assay for the degradation products of procarbazine hydrochloride was developed using high-pressure liquid chromatography. The method uses a buffered methanol-water mobile phase on a reversed-phase column. Concentrations of degradation products as low as 0.04 mg/ml, 0.02% degradation, can be quantitated using an internal standard of cinnamyl alcohol. The typical range for degradation products in procarbazine capsules is 0.1-0.5% after as long as 4.5 years.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0859e3e19813940ec26fa7a475827115 https://doi.org/10.1002/jps.2600670345 Zobrazit plný text záznamu Plný text