18F-FDG-PET/CT in Patients Affected by Differentiated Thyroid Carcinoma with Positive Thyroglobulin Level and Negative 131I Whole Body Scan. It's Value Confirmed by a Bicentric Experience
| Autor: | Raffaele Giubbini, Arnoldo Piccardo, Bassam Dib, Domenico Albano, Francesco Bertagna, Giovanni Bosio |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Lung Neoplasms medicine.medical_treatment Whole body imaging Population Bone Neoplasms Sensitivity and Specificity Thyroglobulin 030218 nuclear medicine & medical imaging Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Biomarkers Tumor Medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging Thyroid Neoplasms education Thyroid cancer Retrospective Studies Pharmacology education.field_of_study business.industry Thyroid Thyroidectomy Area under the curve Middle Aged medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis Lymph Node Excision Lymphadenectomy Female Neoplasm Recurrence Local Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | Current radiopharmaceuticals. 9(3) |
| ISSN: | 1874-4729 |
| Popis: | Background: 18 F-FDG-PET/CT applications in the field of differentiated thyroid cancer (DTC) are continuously growing. Objective: To retrospectively analyze in a wide population enrolled in two nuclear medicine centers the diagnostic value of 18 F-FDG-PET/CT in patients treated with 131 I and negative 131 I-WBS but in presence of Tg levels higher than 1ng/ml after TSH stimulation. Method: From September 2005 to December 2014, 154 patients affected by DTC, treated with 131 I with negative 131 I-WBS and Tg≥1ng/ml underwent 18 F-FDG-PET/CT. Results: 66 patients (43%) had a negative 18 F-FDG-PET/CT (mean Tg=7.7ng/ml; SD=9.6) and 88 (57%) a positive scan (mean Tg=169.4; SD=294.6) documenting bone, pulmonary, lymph-node metastases and local recurrences. There was no statistically significant correlation between 18 F-FDGPET/ CT results and sex, previous lymphadenectomy, the “on-” or “off-therapy” state; on the contrary, there was a statistically significant correlation between PET results and primary tumor size (T1–T2 vs. T3–T4). ROC analysis showed that the highest accuracy in terms of best compromise between sensitivity and specificity (sensitivity= 71,6%; specificity=92,4%; AUC area under the curve= 0.807) is achieved when the 12ng/mL is considered the Tg cut-off value to interpret the results. Conclusion: Our study confirm in a wide population that 18 F-FDG-PET/CT is useful in evaluating patients affected by DTC, negative 131 I-WBS and Tg>1ng/ml, identifying 12ng/ml as the Tg level cut-off over which is better to perform the study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|