Dengue Vaccine: The Need, the Challenges, and Progress
| Autor: | Alan L. Rothman, Francis A. Ennis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Protective immunity business.industry Dengue Vaccines Dengue Virus Dengue virus Vaccines Attenuated medicine.disease_cause medicine.disease Virology Dengue fever Dengue Major Articles and Brief Reports 03 medical and health sciences 030104 developmental biology Infectious Diseases medicine Humans Immunology and Allergy business Dengue vaccine |
| Zdroj: | Journal of Infectious Diseases. 214:825-827 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiw068 |
| Popis: | The ideal dengue vaccine will provide protection against all serotypes of dengue virus and will be economical and uncomplicated in its administration. To determine the ability of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable neutralizing antibody response, a placebo-controlled clinical trial was performed in 48 healthy adults who received 2 doses of vaccine or placebo administered 12 months apart. Evaluation of safety, vaccine viremia, and neutralizing antibody response after each dose indicated that the first dose of vaccine was capable of preventing infection with the second dose, thus indicating that multiple doses are unnecessary. |
| Databáze: | OpenAIRE |
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