Beneficial action of resveratrol: How and why?
| Autor: | Gastón Repossi, Gustavo Tomás Díaz-Gerevini, Alejandro Dain, Aldo R. Eynard, Undurti N. Das, María Cristina Tarrés |
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| Rok vydání: | 2016 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine endocrine system diseases Endocrinology Diabetes and Metabolism Apoptosis Resveratrol Antioxidants chemistry.chemical_compound 0302 clinical medicine Stilbenes Metabolic Syndrome Nutrition and Dietetics Microbiota Anti-Inflammatory Agents Non-Steroidal Interleukin-17 NF-kappa B Cell Differentiation purl.org/becyt/ford/3.1 [https] Bioquímica y Biología Molecular Lipoxins Vascular endothelial growth factor Medicina Básica Vascular endothelial growth factor A purl.org/becyt/ford/3 [https] Alzheimer'S Disease medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Biology Proinflammatory cytokine 03 medical and health sciences Internal medicine Cytochrome P-450 CYP1A1 medicine Humans Obesity Autistic Disorder Cell Proliferation Flavonoids Brain-derived neurotrophic factor Tumor Necrosis Factor-alpha Brain-Derived Neurotrophic Factor Type 2 Diabetes Mellitus AMPK Hypoxia-Inducible Factor 1 alpha Subunit Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 chemistry Mitochondrial biogenesis 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/j.nut.2015.08.017 |
| Popis: | Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-α, interluekin-17 (IL-17), and other proinflammatory molecules, and thus is of benefit in autoimmune diseases. In addition, resveratrol inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, explaining its effective action against cancer. Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism. We noted that BDNF protects against cytotoxic actions of alloxan, streptozotocin, and benzo(a)pyrene. Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus, and metabolic syndrome, suggesting that it may augment BDNF synthesis and action. We also observed that BDNF levels are low in type 2 diabetes mellitus and that BDNF enhances production of antiinflammatory lipid, lipoxin A4, whose levels are low in diabetes mellitus. Thus, resveratrol may augment production of lipoxin A4. Resveratrol alters gut microbiota and influences stem cell proliferation and differentiation. These pleiotropic actions of resveratrol may explain the multitude of its actions and benefits. Fil: Diaz Gerevini, Gustavo Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Dain, Alejandro. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina Fil: Tarres, Maria Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Das, Undurti Narasimha. Bioscience Research Centre And Department Of Medicine; India Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina |
| Databáze: | OpenAIRE |
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